Holders Napoli withstood a late Spezia charge for a 4-2 win to advance to the Italian Cup semi-finals on Thursday where they meet Atalanta.
Senegalese defender Kalidou Koulibaly got the first after five minutes with a back-heel kick off an Elseid Hysaj cross.
Piotr Zielinski sent over the top for Hirving Lozano to fire in the second on 20 minutes with the Polish midfielder involved in Matteo Politano’s third goal on the half-hour.
Lorenzo Insigne missed a chance before setting up the fourth with Eljif Elmas beating Spezia goalkeeper Titas Krapikas minutes before the break.
Vincenzo Italiano’s Serie A newcomers, who shocked Roma in the last 16 and beat Napoli at home in the league earlier this month, fought back.
Gennaro Acampora teed up Emanuel Gyasi to slide into goal after 70 minutes, with the former Napoli youth player then scoring himself with a low shot from outside the area past a static David Ospina.
Napoli next play Atalanta with Inter Milan taking on Juventus in the other semi-final which will be played over two legs on February 3 and 10